P53 plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNAPK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage. Chk2 and Chk1 can phosphorylate p53 at Ser20, enhancing its tetramerization, stability and activity. p53 is phosphorylated at Ser392 in vivo and by CAK in vitro. Phosphorylation of p53 at Ser392 is altered in human tumors and has been reported to influence the growth suppressor function, DNA binding and transcriptional activation of p53.
p53廣泛的研究發現P53腫瘤抑制基因對50%以上的人類癌癥具有抑制突變的功能。P53蛋白水平在正常細胞中表達低，在DNA突變時或各種各樣細胞遇難信號時反應增加。該基因突變或缺失是導致許多腫瘤發生的原因。P53同時也是細胞凋亡的調控因子。此抗體可用于P53腫瘤抑制基因功能的研究。
我公司新研發的P53(p53細胞腫瘤抗原)抗體以及配對磷酸化p53 (phospho S371)抗體已經通過檢驗測試已經通過檢驗測試，可以應用于蛋白印跡（WB），免疫組化（IHC），免疫細胞化學（ICC），酶聯免疫吸附試驗（ELISA），免疫沉淀（IP），免疫熒光（IF）實驗。具體信息如下：
編號 產品名稱
PR-1005， P53 Antibody
PR-1005P， p53 (phospho S371) Antibody
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鎮江厚普生物科技有限公司銷售部
2015-10-28