人類Ｔ淋巴細胞白血病病毒（HTLV-1）是導致人類淋巴細胞白血病、慢性脊髓癱瘓等慢性疾病的主要原因之一。Tax是HTLV-1編碼的轉錄因子，盡管它不能直接結合到病毒基因的啟動子即 5′長末端重復序列（LTR）上，但它的轉錄激活活性對于病毒復制是必需的。研究表明，宿主細胞的CREB可以與病毒基因組LTR上21bp的CRE樣序列結合。CRE樣的序列有3個，分別命名為結構域A、B、C。CREB結合于其中的結構域Ｂ。Tax可以通過相互作用與CBP（CREB binding protein）結合，并通過CBP將其攜帶到病毒基因組的啟動子上。CREB-CBP-Tax復合物一旦形成，并結合到病毒基因啟動子上，病毒基因便被激活開始轉錄和復制。HTLV-1 Tax蛋白與NF-κB活性調控蛋白相互作用表明HTLV-1 Tax蛋白通過促進HMGB1mRNA和蛋白的表達，進而激活NF-κB活性。
HTLV-1 causes two distinct human diseases, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma(ATL). The glycoproteins encoded by the env gene of HTLV-1 are essential for interaction with an unidentified receptor on the surface of target cells and play a crucial role in the infection process. Encoded by HTLV-1 Tax is a phospho-oncoprotein that functions as a transcriptional activator. Tax has the ability to modulate the expression and function of many cellular genes and has been crucial to understanding the HTLV-1-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including the CREB/ATF and NFκB pathways. In addition, Tax deregulates the expression of downstream genes, which mediate cell cycle control. The Tax protein of HTLV1 is an autoregulator of enhanced viral RNA transcription and it trans activates the viral 21 bp enhancer.
我公司新研發的磷酸化p-HTLV 1 Tax (Ser288)抗體已經通過檢驗測試，可以應用于蛋白印跡（WB），免疫組化（IHC），免疫細胞化學（ICC），酶聯免疫吸附試驗（ELISA），免疫沉淀（IP），免疫熒光（IF）實驗。具體信息如下：
編號 產品名稱
PR-1027P， p-HTLV 1 Tax (Ser288) antibody
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鎮江厚普生物科技有限公司銷售部
2013-07-10