HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
我公司新研發的HMG-CoA reductase（3-羥-3-甲基戊二酰輔酶A還原酶）抗體以及配對磷酸化HMG-CoA reductase (pSer871)抗體已經通過檢驗測試，可以應用于蛋白印跡（WB），免疫組化（IHC），免疫細胞化學（ICC），酶聯免疫吸附試驗（ELISA），免疫沉淀（IP），免疫熒光（IF）實驗。具體信息如下：
編號 產品名稱
PR-1030， HMG-CoA reductase Antibody
PR-1030P， HMG-CoA reductase (pSer871) Antibody
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鎮江厚普生物科技有限公司銷售部
2013-07-10