Background: FERM domains are roughly 150 amino acids in length and are found in a number of cytoskeletal-associated proteins such as ezrin, radixin, moesin and 4.1 (erythrocyte membrane protein band 4.1), where they provide a link between cytoskeletal signals and membrane dynamics. FRMD7 (FERM domain-containing protein 7) is a 714 amino acid protein containing one FERM domain. Localizing to cell projection, FRMD7 is expressed in liver, kidney and pancreas with low levels of expression found in heart and developing neural retina as well as adult and embryonic brain. FRMD7 plays a role in neurite development and may also contribute to the control of eye movement and gaze stability. Defects in FRMD7 have been linked to X-linked congenital nystagmus, an early onset disorder characterized by horizontal pendular oscillations of the eye and decreased visual acuity. FRMD7 exists as two isoforms due to alternative splicing events.
Description: Rabbit polyclonal to FRMD7
Immunogen: KLH conjugated synthetic peptide derived from FRMD7
Specificity: ·Reacts with Human, Mouse, Pig, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 82 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry: 1/100;
·Immunofluorescence: 1/50-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
