Background: G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR142 (G protein-coupled receptor 142), also known as PGR2, is a 462 amino acid multi-pass membrane protein that functions as an orphan receptor and belongs to the GPR1 family. Expressed at highest levels in the ventrolateral region of caudate putamen, zona incerta, medial mammillary nucleus and habenular nucleus, GPR142 is encoded by a gene that maps to human chromosome 17q25.1.
Description: Rabbit polyclonal to GPR142
Immunogen: KLH conjugated synthetic peptide derived from GPR142
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 51 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
