Background: IgE Fc Receptor I binds to the Fc region of immunoglobulin e chain with high affinity, and is responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators such as histamines, responsible for the manifestations of allergy. IgE Fc Receptor I also induces the secretion of important lymphokines, effectors of the hypersensitivity response.Expression of IgE Fc RI mRNA appears to be highly specific and has been identified in mast cells and IL-3 dependent myeloid-monocyte precursor. Alternative splicing of the genomic transcript for the a chain has also been identified.
Description: Rabbit polyclonal to Fc epsilon RI
Immunogen: KLH conjugated synthetic peptide derived from Fc epsilon RI
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 30 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
