Background: The Thrombospondin proteins (TSP 1-5) compose a family of glycoproteins that are involved in cell-to-cell and cell-to-matrix signaling. These extracellular, cell-surface proteins form complexes of both homo- and hetero-multimers. Thrombospondins play a role in development, aggregation of platelets, adhesion and migration of cells and progression of cells through the growth cycle. Thrombospondin 1 is released from platelets in response to Thrombin stimulation and is a transient component of the extracellular matrix of developing and repairing tissues. Thrombospondin 2 shares a high degree of homology with Thrombospondin 1, and is thought to have overlapping but unique functions. Thrombospondin 3 is a developmentally regulated heparin-binding protein. Thrombospondin 4 is neuronally expressed and stimulates neurite outgrowth.
Description: Rabbit polyclonal to Thrombospondin 2
Immunogen: KLH conjugated synthetic peptide derived from Thrombospondin 2
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 129 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
