Background: BZW1 (basic leucine zipper and W2 domains 1), also known as BZAP45, is a 419 amino acid member of the BZW family that contains one W2 domain and enhances histone H4 gene transcription. Existing as two alternatively spliced isoforms, BZW1 is expressed in day 3 embryos and is encoded by a gene that maps to human chromosome 2q33.1. Chromosoe 2 consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alström syndrome is due to mutations in the ALMS1 gene.
Description: Rabbit polyclonal to BZW1
Immunogen: KLH conjugated synthetic peptide derived from BZW1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 48 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
