Background: Pael-R (Parkin-associated endothelin receptor-like receptor), also known as GPR37 (G protein-coupled receptor 37), EDNRBL or ETBR-LP-1 (endothelin B receptor-like protein 1), is a 613 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor 1 family. Pael-R is expressed in spinal cord and brain, with lower levels found in liver, testis and placenta. When overexpressed, Pael-R causes cells to unfold and accumulate, eventually causing dopaminergic neuronal death in juvenile Parkinson disease (PDJ). Pael-R functions as an orphan receptor and also forms a complex with CHIP, HSP 70 and Parkin. The gene encoding Pael-R maps to human chromosome 7, which comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome and Williams-Beuren syndrome.
Description: Rabbit polyclonal to GPR37
Immunogen: KLH conjugated synthetic peptide derived from GPR37
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 67 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry: 1/100;
·Immunofluorescence: 1/50-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
