Background: G protein-coupled receptors (GPRs or GPCRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, are members of the largest protein family and play a role in many different stimulus-response pathways. G protein-coupled receptors mediate extracellular signals into intracellular signals (G protein activation). They respond to a wide variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR proteins are usually integral seven pass membrane proteins with some conserved amino acid regions. GPR113 (G protein-coupled receptor 113), also known as PGR23 (G-protein coupled receptor PGR23), is a 1,079 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor 2 family and LN-TM7 subfamily. Localizing to cell membrane and containing one GPS domain, GPR113 may function as an orphan receptor. GPR113 exists as two isoforms due to alternative splicing events.
Description: Rabbit polyclonal to GPR113
Immunogen: KLH conjugated synthetic peptide derived from GPR113
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 116 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
