Background: ABI2 (Abelson interactor 2) belongs to the ABI family. The Abelson interactors are among a group of proteins that interact with Abl tyrosine kinase, a non-receptor tyrosine kinase whose activation results in the regulation of cytoskeleton function, cell growth and apoptosis in response to a variety of biological stimuli. ABI2 may act in regulation of cell growth and transformation by interacting tyrosine kinases ABL1 and/or ABL2 and may be involved in cytoskeletal reorganization and regulation of the ABL1/c-Abl-mediated phosphorylation of MENA. ABI2 is also known to be a tumor suppressor and a cell migration inhibitor.
Description: Rabbit polyclonal to ABI2
Immunogen: KLH conjugated synthetic peptide derived from ABI2
Specificity: ·Reacts with Human, Mouse, Pig, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 56 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
