Background: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. These enzymes differ in their tissue distributions and substrate specificities, although the gene structure (number and length of exons) is similar among family members. Chondro-itin 4-O-sulfotransferase-2 (C4ST-2), also referred to as carbohydrate sulfotransferase 12 (CHST12), catalyzes the transfer of sulfate groups to position four of N-acetylgalactosamine (GalNAc) residues in dermatan and chondroitin. This sulfation is required for proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis. C4ST-2 may play a role that is complementary to that of C4ST-1 in chondroitin and dermatan sulfate synthesis.
Description: Rabbit polyclonal to CHST12
Immunogen: KLH conjugated synthetic peptide derived from CHST12
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 48 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
