Background: Sigma Receptor, also known as opioid receptor, sigma 1 (Oprs 1), acts as a modulatory system influencing the analgesic activity of opioid drugs. For example, activation of the Sigma Receptor is induced during the early effects of cocaine. At the cellular level, Sigma Receptor agonists modulate intracellular calcium mobilization and extracellular calcium influx, NMDA-mediated responses and acetylcholine release. In addition, Sigma Receptor agonists alter monoaminergic systems. At the behavioral level, the Sigma Receptor is involved in learning and memory processes, response to stress, depression, neuroprotection and pharmacodependence. Pregnenolone, dehydroepiandrosterone and their sulfate esters behave as Sigma Receptor agonists, while progesterone is a potent antagonist. Sigma Receptor is expressed in the endocrine, immune and other peripheral organ systems, and is expressed in a variety of human tumors. The Sigma Receptor is responsible for the pathogenesis of some psychiatric disorders and may be involved in several diseases of the central nervous system. Opioid analgesia is influenced by many factors, including the Sigma Receptor.
Description: Rabbit polyclonal to Sigma receptor
Immunogen: KLH conjugated synthetic peptide derived from Sigma receptor
Specificity: ·Reacts with Human.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 29 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
