Background: PCMTD1 (protein-L-isoaspartate O-methyltransferase domain-containing protein 1) is a 357 amino acid cytoplasmic protein that is a member of the L-isoaspartyl/D-aspartyl protein methyltransferase family. Members of this family participate in the degradation and/or repair of damaged proteins by specifically recognizing isomerized Asp or Asn residues in peptides and proteins. PCMTD1 is related to PCMT1, which catalyzes the conversion of abnormal L-isoaspartyl and D-aspartyl residues to methyl esters that may then spontaneously hydrolyze to re-form normal aspartyl residues. In mice lacking PCMT1, damaged proteins accumulate in a variety of tissues and the phenotypic result is progressive epilepsy and death at an early age. There are two isoforms of PCMTD1 that are produced as a result of alternative splicing events.
Description: Rabbit polyclonal to PCMTD1
Immunogen: KLH conjugated synthetic peptide derived from PCMTD1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 41 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/50-200;
·Immunocytochemistry: 1/100;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
