Background: CROP (Cisplatin resistance-associated overexpressed protein), also designated cAMP regulatory element-associated protein 1 (CREAP-1), Okadaic acid-inducible phosphoprotein OA48-18 or Luc7-like protein 3 (LUC7L3), is a 432 amino acid protein that belongs to the Luc7 family. It is ubiquitously expressed and localizes to the nucleus. The N-terminal half of the CROP protein contains cysteine/histidine motifs and leucine zipper-like repeats, while the C-terminal half is mostly hydrophilic and comprises domains rich in lysine/glutamate residues, arginine/glutamate residues and arginine/serine residues. CROP binds to cAMP regulatory element DNA sequence and may be involved in RNA splicing. The activity of CROP is modulated upon phosphorylation by SRPK1, SRPK2 and Clk1.
Description: Rabbit polyclonal to CROP
Immunogen: KLH conjugated synthetic peptide derived from CROP
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 51 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
