Background: Pancreatic Polypeptide (PP) and Pancreatic Icosapeptide (PI) are both deduced from the pancreatic prohormone precursor. The two peptide sequences are seperated by a Gly-Lys-Arg cleavage and amidation site. The Pancreatic Polypeptide lies on the N-terminal side of this cleavage site while the Pancreatic Icosapeptide lies on the C-terminal side. The prohormone precursor is produced by the endocrine F cells of the pancreatic islets and, in response to food intake, the Pancreatic Polypeptide is released into the circulation. The Pancreatic Polypeptide is a member of the neuropeptide Y (NPY) family of hormones that bind to Y receptors. In particular, it binds to Y4 receptors and functions as an anorexigenic hormone.
Description: Rabbit polyclonal to Pancreatic Polypeptide
Immunogen: KLH conjugated synthetic peptide derived from Pancreatic Polypeptide
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 10 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
