Background: Parafibromin is encoded by the endocrine tumor suppressor gene CDC73 (cell division cycle 73, Paf1/RNA polymerase II complex component), alternatively known as the HRPT2 (hyperparathyroidismjaw tumor syndrome 2) gene. Parafibromin is a tumor suppressor involved in transcriptional and post-transcriptional control pathways, such as cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Defects in parafibromin are the cause of parathyroid gland tumors.
Description: Rabbit polyclonal to Parafibromin
Immunogen: KLH conjugated synthetic peptide derived from Parafibromin
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 60 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
