Background: NCAM (neural cell adhesion molecule 1; CD56 ) is a cell adhesion molecule involved in neuron-neuron adhesion (through the formation of zipper-like NCAM-complexes), neurite fasciculation, outgrowth of neurites, etc. NCAM is also involved in heterophilic interactions with a number of proteins and extracellular matrix molecules. Some of these heterophilic interactions are mutually exclusive, and some interfere with or are dependent on homophilic NCAM interactions. Furthermore, both homo- and heterophilic interactions are modulated by posttranslational modifications of NCAM. Heterophilic NCAM-interactions initiate several intracellular signal transduction pathways ultimately leading to biological responses involving cellular differentiation, proliferation, migration and survival. It is type I membrane protein.
Description: Rabbit polyclonal to CD56
Immunogen: KLH conjugated synthetic peptide derived from CD56
Specificity: ·Reacts with Human, Mouse, Guinea pig and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 93 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Flow Cytometry: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
