Background: All lower eukaryotes possess a single ATG9 gene, and all vertebrates likely possess two genes, ATG9A and ATG9B, suggesting that an ATG9 gene duplication occurred before the divergence of fish. The overlapping orientation of the ATG9B and NOS3 genes is also conserved in mammals and frogs, indicating conservation in vertebrates. Atg9b (ATG9 autophagy related 9 homolog B), also known as SONE, APG9L2 (autophagy 9-like 2 protein) or NOS3AS (nitric oxide synthase 3-overlapping antisense gene protein), is a 924 amino acid protein belonging to the ATG9 family. Sixteen known human ATG genes exist, of which four (Atg2B, Atg5, Atg9B and Atg12) possess mononucleotide repeats with seven or more nucleotides. Atg9B frameshift mutations may contribute to development of cancer via disruption of autophagy. Encoded by a gene that maps to human chromosome 7q36.1, Atg9b contains between six and eight putative transmembrane domains. Conserved in chimpanzee, dog, cow, mouse and rat, Atg9b is highly expressed in placenta, pituitary, testis, uterus and lung, and to a lesser extent in most other tissues.
Description: Rabbit polyclonal to ATG9B
Immunogen: KLH conjugated synthetic peptide derived from ATG9B
Specificity: ·Reacts with Human, Mouse, Pig, Dog, Rabbit and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/200-500. Predicted Mol wt: 101 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/200;
·ELISA: 1/1000;
·Optimal working dilutions must be determined by the end user.
