Background: Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Cloning of complementary DNAs encoding adiponectin receptors 1 (AdipoR1) has shown that AdipoR1 is abundantly expressed in skeletal muscle. This receptor is structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1 or suppression of AdipoR1 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin. Widely expressed. Highly expressed in skeletal muscle. ADR 1 is expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
Description: Rabbit polyclonal to AdipoR1
Immunogen: KLH conjugated synthetic peptide derived from AdipoR1
Specificity: ·Reacts with Human, Mouse, Dog, Cow, Pig, Guinea pig, Rabbit and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/500-1000. Predicted Mol wt: 41 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/200-500;
·ELISA: 1/1000;
· Optimal working dilutions must be determined by the end user.
