Background: The FK506-binding proteins (FKBPs) are peptidyl prolyl cis/trans isomerases. Members of the FKBP family have been shown to participate in signal transduction. FKBPs are intracellular receptors for the immunosuppressive drug FK506. The FKBP/FK506 complex exerts its immunosuppressive effects by inhibiting calcineurin, a calcium and calmodulin dependent serine/threonine phosphatase that functions as a critical signaling molecule during T cell activation. PPIases accelerate the folding of proteins during protein synthesis.
Description: Rabbit polyclonal to FKBP11
Immunogen: KLH conjugated synthetic peptide derived from FKBP11
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 25 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100;
·ELISA: 1/500;
· Optimal working dilutions must be determined by the end user.
