Background: Phosphocholine (PC) is an intermediate in the synthesis of phosphatidylcholine in tissues. Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP + Choline into Phosphocholine and ADP. Phosphocholine is a molecule found for example in lecithin. It is also used by nematodes and human placentas to suppress an immune response by their hosts. It is one of the natural constituents of hens' eggs (and many other eggs), in the form of Egg-PC, which is often used in biomimetic membrane studies. It is also one of the binding targets of C-Reactive Protein (CRP). Thus when a cell is damaged, CRP binds to phosphocholine beginning the recognition and phagocytotic immunologic response.
Description: Rabbit polyclonal to Phosphocholine
Immunogen: KLH conjugated synthetic peptide derived from Phosphocholine
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/500-1000;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/200-500;
·ELISA: 1/500;
· Optimal working dilutions must be determined by the end user.
