Background: PHGDH is 544 amino acids in length. Two distinct mRNA transcripts that encode for PHGDH in normal human tissues are dominant 2.1 kb mRNA, which is highly expressed in prostate, testis, ovary, brain, liver, kidney, and pancreas, and weakly expressed in thymus, colon and heart, and 710 bp mRNA, which is highly expressed in heart and skeletal muscle. PHGDH is regulated at the transcriptional level depending on tissue specificity and cellular proliferative status. PHGDH is also highly expressed in adult and fetal brain tissues. Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
Description: Rabbit polyclonal to PHGDH
Immunogen: KLH conjugated synthetic peptide derived from PHGDH
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 57 kDa;
·Immunohistochemistry (Paraffin/frozentissue section): 1/100-500;
·Immunocytochemistry: 1/100;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
