Background: MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. MAP3K8 activates IkappaB kinases, and thus induces the nuclear production of NF-kappaB. It also promotes the production of TNF-alpha and IL-2 during T lymphocyte activation. There are two isoforms of MAP3K8: a 58 kDa and a 53 kDa form. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer 58 kDa form undergoes phosphorylation on Ser residues mainly, and the shorter 53 kDa form undergoes phosphorylation on both Ser and Thr residues.
Description: Rabbit polyclonal to MAP3K8
Immunogen: KLH conjugated synthetic peptide derived from MAP3K8
Specificity: ·Reacts with Human, Mouse, Rabbit, Dog, Cow and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 53 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
· Optimal working dilutions must be determined by the end user.
