Background: Septins are members of a conserved family of cytoskeletal GTPases, specifically belonging to the large superclass of P-loop GTPases. Septin proteins form homo- and hetero-oligomeric polymers that accumulate into higher-order filaments which may function as dynamic protein scaffolds. Septins play an important role in vesicle trafficking, apoptosis, cytoskeleton remodeling, infection, neurodegeneration, neoplasia and cytokinesis. Septin 9 is expressed in lymphoid tissues and has an elaborate genomic structure. There are 15 different isoforms of Septin 9, made possible by intermixing five alternate amino termini and three alternate carboxy termini. Changes in the levels of Septin 9 by overexpression of these individual isoforms can disturb cellular behavior and may be implicated in neoplasia. Septin 9 is commonly upregulated in ovarian tumors and may be linked to hereditary neuralgic amyotrophy (HNA). HNA is an autosomal dominant, recurrent neuropathy affecting the brachial plexus.
Description: Rabbit polyclonal to MSF
Immunogen: KLH conjugated synthetic peptide derived from MSF
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 64 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
