Background: APPL is involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The APPL binds to RAB5A/Rab5 through N terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation.
Description: Rabbit polyclonal to APPL1
Immunogen: KLH conjugated synthetic peptide derived from APPL1
Specificity: ·Reacts with Human, Mouse, Rabbit, Pig, Dog, Cow and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 80 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
