Background: Fibrinogen, the main protein of the blood coagulation system, becomes activated into fibrin by thrombin and fibrin polymerization during the process of blood coagulation. Plasmin then digests the fibrin clot and fibrin degradation products of different molecular weights are released into the bloodstream. D-dimer is the main and smallest product of fibrin degradation, comprised of 111-197 amino acids in the α-chain, 134-461 amino acids in the β-chain, and 88-406 amino acids in the γ-chain of fibrinogen. All chains are cross-linked by disulfide bonds, and the dimeric structure is held by two isopeptide bonds between C-terminal parts of γ-chains. D-dimer fragments can be measured easily in plasma and whole blood, and the presence or absence of D-dimer may be useful in the diagnostic evaluation of venous thromboembolism.
Description: Rabbit polyclonal to D-Dimer
Immunogen: KLH conjugated synthetic peptide derived from D-Dimer
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 180 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
