Background: BCL2L15, is a 163 amino acid protein and novel member of the Bcl-2 family that contains both BH2 and BH3 regions, but not BH1, BH4 or a C-terminal hydrophobic membrane anchor. Like Bcl-GL, BCL2L15 does not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins. BCL2L15 localizes to cytoplasm, but unlike Bcl-GL, BCL2L15 does not associate with organelles. Existing as four alternatively spliced isoforms, the pro-apoptotic isoforms of BCL2L15 may help to protect against the development of human gastrointestinal malignancy. BCL2L15 is found at low levels in stomach, ovary, bone marrow and spleen, but BCL2L15 is highly expressed in mammary gland during pregnancy, suggesting that BCL2L15 may play a role in mammary development. BCL2L15 appears to be a cytosolic protein whose gene maps to chromosome 1p13.2. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.
Description: Rabbit polyclonal to BCL2L15
Immunogen: KLH conjugated synthetic peptide derived from BCL2L15
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 18 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
