Background: Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes responsible for catalyzing the reversible hydration of carbon dioxide. CAs show extensive diversity in their distribution and subcellular localization. They are involved in a variety of biological processes, including calcification, bone resorption, respiration, acid-base balance and the formation of aqueous humor, saliva, gastric juice and cerebrospinal fluid. CA XIII, also referred to as carbonate dehydratase XIII, is predominantly expressed in spleen, prostate, thymus, ovary, testis, colon and small intestine localizing to the cytoplasm. It exhibits highest homology with family members CA I, CA II and CA III. CA XIII may play a role in embryogenesis. Efficient inhibitors of CA XIII activity are sulfanilyl-sulfonamide type inhibitors.
Description: Rabbit polyclonal to CA13
Immunogen: KLH conjugated synthetic peptide derived from CA13
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 29 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
