Background: ADAMs are expressed in a wide range of mammalian tissues and several are abundantly expressed in the male reproductive tract. ADAM2, also designated fertilin b and PH30 b, forms a heterodimer with ADAM1 (fertilin a or PH30 a) on the surface of spermatozoa, which mediates gamete cell adhesion during fertilization. ADAM2 utilizes an ECD motif to interact with integrins expressed on the egg plasma membrane. The gene encoding human ADAM2 maps to chromosome 8p11.2.
Description: Rabbit polyclonal to ADAM2
Immunogen: KLH conjugated synthetic peptide derived from ADAM2
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 64 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
