Background: FPR1 (Formyl peptide receptor 1), a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response. Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FRP1, attract polymorphonuclear neutrophils to sites of infection. FRP1 promotes the phosphorylation and downregulation of CCR5, which has been shown to inhibit HIV infection. Therefore, ligands for FRP1 may be able to inhibit HIV infection.
Description: Rabbit polyclonal to FPR1
Immunogen: KLH conjugated synthetic peptide derived from FPR1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 38 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
