Background: The serum- and glucocorticoid-regulated kinases (SGKs) include SGK1, SGK2 and SGK3 and are members of the serine/threonine protein kinase family. SGKs play an important role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. The SGKs display structural and sequence similarity to the PKB/Akt family except for the absence of a Pleckstrin homology (PH) domain. The SGKs are also downstream targets of PI 3-kinase-stimulated growth factor signaling. They can all phosphorylate NEDD4-1, which subsequently activates various channels and transporters including ENaC, KV1.3 or EAAT1. Aldosterone induces the expression of SGK1, but not SGK2 or SGK3. SGK3 is ubiquitously ex-pressed, but SGK2 only shows significant levels of expression in liver, kidney and pancreas.
Description: Rabbit polyclonal to SGK2
Immunogen: KLH conjugated synthetic peptide derived from SGK2
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 48 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
