Background: The nuclear Dbf2-related kinases (NDR-1 and NDR-2) participate in the regulation of cell division and morphology, and may be implicated in tumor progression. NDR-1 and NDR-2 share 86% amino acid identity, but differ in their expression pattern. NDR-1 localizes to the nucleus, while NDR-2/STK38L exhibits punctate cytoplasmic distribution. Also, NDR-1 expression appears highest in spleen, lung and thymus, whereas NDR-2 shows highest expression in the gastrointestinal tract. However, both NDR-1 and NDR-2 are regulated by phosphorylation and by the Ca2+-binding protein S100B. NDR-1 and NDR-2 may also play a role in the HIV-1 life cycle. Both proteins are cleaved by the HIV-1 protease (PR), which inhibits their enzymatic activity and alters the subcellular localization of NDR-2. The genes encoding human NDR-1 and NDR-2 map to chromosomes 6p21 and 12p11.23, respectively.
Description: Rabbit polyclonal to STK38L
Immunogen: KLH conjugated synthetic peptide derived from STK38L
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 54 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
