Background: T-cell Leukemia/Lymphoma Protein 1A (TCL-1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL). T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and the TCL1A gene on 14q32.1. TCL-1A is a member of a unique family of beta barrel proteins that bind small hydrophobic ligands and function in cell regulation. TCL-1A is an all-beta protein containing an eight-stranded antiparallel beta barrel which consists of two four-stranded beta-meander motifs. The two motifs are related by a twofold axis and connected by a long loop. TCL-1A forms a tight crystallographic dimer. TCL-1A is expressed in pre-B cells, in immature thymocytes, at low levels in activated T cells, and in the cytoplasm.
Description: Rabbit polyclonal to TCL1
Immunogen: KLH conjugated synthetic peptide derived from TCL1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 13 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
