Background: CDIP (cell death-inducing protein), also known as transmembrane protein I1, LITAF-like protein or C16orf5, is a 208 amino acid protein that is highly expressed in brain, with lower levels found in liver, heart, skeletal muscle, pancreas and kidney. A member of the LITAF family, CDIP localizes to the nucleus and functions as a p53 apoptotic effector. The gene encoding CDIP maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Description: Rabbit polyclonal to C16orf5
Immunogen: KLH conjugated synthetic peptide derived from C16orf5
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 22 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
