Background: COMMD family members are a group of evolutionary conserved proteins that share a common COMM domain at the extreme C-terminus, which provides an interface for protein-protein interactions. Most, if not all, COMMD proteins have been found to play a role in the regulation NF˚B and, despite their similarities, seem to function in unique and non-redundant pathways. COMMD proteins may also play a role in the function of epithelial sodium channels, cell proliferation, copper homeostasis and in the regulation of the ubiquitin pathway. As a member of the COMMD family, COMMD5 (COMM domain-containing protein 5), also known as HCaRG (hypertension-related calcium-regulated gene protein), is a 224 amino acid protein that is negatively regulated by extracellular calcium concentrations. Due to lower proliferation rates observed in COMMD5-transfected HEK293 cells, it is suggested that COMMD5 may play a regulatory role in cell proliferation. COMMD5 is localized to the nucleus and is expressed in stomach, liver, kidney, heart, adrenal gland and jejunum, with higher levels of mRNA expression found in hypertensive animals.
Description: Rabbit polyclonal to COMMD5
Immunogen: KLH conjugated synthetic peptide derived from COMMD5
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 27 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
