Background: COMMD family members are a group of evolutionary conserved proteins that share a common COMM domain at the extreme C-terminus, which provides an interface for protein-protein interactions. Of the ten family members, the role of COMMD1, also known as MURR1, is best characterized, functioning to inhibit TNF-induced NFκB p50 and to facilitate biliary copper excretion within hepatocytes. Most, if not all, COMMD proteins have been found to play a role in the regulation NFκB and, despite their similarities, seem to function in unique and non-redundant pathways. COMMD proteins may also play a role in the function of epithelial sodium channels, cell proliferation, copper homeostasis and in the regulation of the ubiquitin pathway. As a member of the COMMD family, COMMD2 (COMM domain-containing protein 2) is a 199 amino acid protein containing the characteristic COMM domain at its C-terminus.
Description: Rabbit polyclonal to COMMD2
Immunogen: KLH conjugated synthetic peptide derived from COMMD2
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 23 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
