Background: Neuronal and cardiac cells are excited by voltage-gated ion channels. Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. Mutations interfering with potassium ion channels are known to cause a variety of disorders. A subunit of the potassium channel, KCNG3 is a 436 amino acid protein that modulates channel activity and forms a heteromultimer with KV2.1, KV3.1 and KCNF1. KCNG3 contains an S4 domain that may serve as the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. KCNG3 localizes to the membrane, however it must be associated with KV2.1 and possibly another partner to get inserted in the plasma membrane. KCNG3 is detected in testis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland, spinal cord and in many parts of the brain, with the exception of the cerebellum.
Description: Rabbit polyclonal to KCNG3
Immunogen: KLH conjugated synthetic peptide derived KCNG3
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 50 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
