Background: The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins (FRPs) have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The FRPs are involved in the Wnt signaling pathway by regulating the intracellular levels of beta-catenin. Frizzled-3 (Fz-3) is a widely expressed, 666 amino acid protein, with relatively high expression in the central nervous system. Frizzled-3 has been associated with schizophrenia and has been shown to play a role in neural crest formation and hair follicle development. Two named isoforms of frizzled-3 exist as a result of alternative splicing events.
Description: Rabbit polyclonal to Frizzled 3
Immunogen: KLH conjugated synthetic peptide derived from Frizzled 3
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 76 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
