Background: Rheumatoid Factor is an antibody that recognizes the Fc portion of immuno-globulin G (IgG). Rheumatoid Factor and IgG form an immune complex that can activate various inflammatory processes in the body. A blood test is clinically used to detect the presence of Rheumatoid Factor, since high levels of Rheumatoid Factor are indicative of rheumatoid arthritis and Sjogren’s syndrome, an autoimmune disorder in which immune cells attack and destroy the exocrine glands that produce tears and saliva. This factor is also associated with a higher tendency to develop non-joint manifestations of rheumatoid disease, such as rheumatoid nodules and rheumatoid lung disease.
Description: Rabbit polyclonal to Rheumatoid Factor
Immunogen: KLH conjugated synthetic peptide derived from Rheumatoid Factor
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 12 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
