Background: Small-conductance, calcium-activated K+ channels (SK channels) are activated in a voltage-independent manner, and they have a small unit conductance and high sensitivity to calcium. SK channels 1-3 contain intracellular N- and C- termini and 6 conserved transmembrane segments. SK1 expression is restricted to the brain whereas SK2 and SK3 are more widely expressed. SK channels influence most excitable cells and participate in afterhyperpolarization (AHP) and spike-frequency adaptation. Human SK3 is a 731 amino acid protein that is expressed in muscles upon denervation, and it is a component of the presynaptic compartment in mature neuromuscular junctions. SK3 may also play a regulatory role in synaptic transmission.
Description: Rabbit polyclonal to KCNN3
Immunogen: KLH conjugated synthetic peptide derived from KCNN3
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 82 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
