Background: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. These cytosolic enzymes differ in their tissue distributions and substrate specificities, although the gene structure (number and length of exons) is similar among family members. Sulfotransferases are primarily expressed in liver and adrenal tissues where they add sulfate to steroids and bile acids. C4ST-1 (chondroitin 4-sulphotransferase-1) transfers sulfate from PAPS (adenosine 3'-phosphate 5'-phosphosulphate) to position 4-O of N-acetylgalactosamine in chondroitin. This sulfation is required for proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis. N-linked oligosaccharides attached to C4ST-1 contribute to the production and stability of the active form of C4ST-1.
Description: Rabbit polyclonal to CHST11
Immunogen: KLH conjugated synthetic peptide derived from CHST11
Specificity: ·Reacts with Human, Mouse, Pig, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 43 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
