Background: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. These cytosolic enzymes differ in their tissue distribution and substrate specificities, although the gene structure (number and length of exons) is similar among family members. Sulfotransferases are primarily expressed in liver and adrenal tissues, where they add sulfate to steroids and bile acids. Chondroitin 6-sulfotransferase-1 (C6ST-1) is a 486 amino acid protein that localizes in the Golgi apparatus, where it sulfates both chondroitin and keratan sulfate. C6ST-1 is developmentally regulated in many different tissues, with expression continuing through adulthood in the spleen. When C6ST-1 expression is upregulated, the motility of Schwann cells that guide growing axons through both developmental and injured environments increases.
Description: Rabbit polyclonal to CHST3
Immunogen: KLH conjugated synthetic peptide derived from CHST3
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 55 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
