Background: C35, also known as XTP4 (HBV X-transactivated gene 4) and protein C17orf37, is a 115 amino acid cytoplasmic protein that is a member of the SelWTH protein family. SelWTH proteins contain a thioredoxin-like fold and a conserved CxxC or CxxU motif, suggesting that they may play functional role in redox reactions. Although found at trace levels in normal breast ductal epithelium and testis, expression of C35 is robust in infiltrating ductal carcinomas of the breast, lobular carcinoma, as well as distant metastases of breast cancer such as liver, lung and skin. The prevalence and abundance of C35 overexpression in tumors suggest that it may be an appropriate bio-marker for diagnosis and a potential target for therapeutic intervention.
Description: Rabbit polyclonal to XTP4
Immunogen: KLH conjugated synthetic peptide derived from XTP4
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 12 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
