Background: GM2/GD2 synthase is a 533 amino acid protein encoded by the human gene B4GALNT1. The GM2 and GD2 gangliosides are sialic acid-containing glyco-sphingolipids that play a role in signal transduction and cell-cell recognition. GM2/GD2 synthase is expressed abundantly in normal brain tissue of vertebrates. It contains a single 18 amino acid hydrophobic segment near the amino-terminus flanked by basic residues. GM2/GD2 synthase primarily controls the balance between expression of simple and complex gangliosides at the cell surface. The ganglioside GD2 is expressed using GM2/GD2 synthase in almost all neuroblastomas (NBs) as well as other neuroectoderm-derived tumor cells, such as malignant melanoma, adult T cell leukemia and some colon and gastric cancers. GM2/GD2 synthase is a useful marker for NBs, and may aid in evaluating adjuvant treatment efficacy in neuroblastoma with prognostic potential.
Description: Rabbit polyclonal to B4GALNT1
Immunogen: KLH conjugated synthetic peptide derived from B4GALNT1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 59 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
