Background: CDNF is an ARMET family member that is known to be a trophic factor for dopamine neurons. CDNF has been shown to prevent the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. CDNF application will restore the dopaminergic function that is reduced by lesions formed from administering 6-OHDA. CDNF further prevents the degeneration of dopaminergic neurons in substantia nigra. CDNF is expressed at high levels in the heart, skeletal muscle, testis and brain. In brain, CDNF has selective expression with the highest being detected in the Purkinje cells of the cerebellum and in regions of the brain stem, including the locus coeruleus.
Description: Rabbit polyclonal to CDNF
Immunogen: KLH conjugated synthetic peptide derived from CDNF
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 21 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
